Version 5.4
Homo sapiens Protein: UNC119B
Summary
InnateDB Protein IDBP-60984.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC119B
Protein Name unc-119 homolog B (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344942
InnateDB Gene IDBG-60982 (UNC119B)
Protein Structure
UniProt Annotation
Function Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. {ECO:0000269PubMed:22085962}.
Subcellular Localization Cell projection, cilium {ECO:0000269PubMed:22085962}. Note=Enriched at the transition zone and extended into the proximal end of the cilium.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0042953 lipoprotein transport
GO:0060271 cilium morphogenesis
Cellular Component
GO:0035869 ciliary transition zone
Protein Structure and Domains
PDB ID
InterPro IPR008015 GMP phosphodiesterase, delta subunit
IPR014756 Immunoglobulin E-set
PFAM PF05351
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NIH7
PhosphoSite PhosphoSite-NP_001074002
TrEMBL
UniProt Splice Variant
Entrez Gene 84747
UniGene Hs.127610
RefSeq NP_001074002
HUGO HGNC:16488
OMIM
CCDS CCDS31914
HPRD
IMGT
EMBL AC069234 AK126367 BC004815 CH471054
GenPept EAW98216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca