InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL19

Summary

InnateDB Protein

IDBP-61013.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL19

Protein Name

chemokine (C-C motif) ligand 19

Synonyms

CKb11; ELC; MIP-3b; MIP3B; SCYA19;

Species

Homo sapiens

Ensembl Protein

ENSP00000308815

InnateDB Gene

IDBG-61011 (CCL19)

Protein Structure

UniProt Annotation

Function

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269PubMed:9498785}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	10 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0031732	CCR7 chemokine receptor binding
GO:0031735	CCR10 chemokine receptor binding
GO:0042379	chemokine receptor binding
GO:0048020	CCR chemokine receptor binding

Biological Process

GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002407	dendritic cell chemotaxis
GO:0002408	myeloid dendritic cell chemotaxis
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007154	cell communication
GO:0007257	activation of JUN kinase activity
GO:0009615	response to virus
GO:0010560	positive regulation of glycoprotein biosynthetic process
GO:0031295	T cell costimulation
GO:0032320	positive regulation of Ras GTPase activity
GO:0032735	positive regulation of interleukin-12 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034695	response to prostaglandin E
GO:0042102	positive regulation of T cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045807	positive regulation of endocytosis
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048469	cell maturation
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050921	positive regulation of chemotaxis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051897	positive regulation of protein kinase B signaling
GO:0060491	regulation of cell projection assembly
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071731	response to nitric oxide
GO:0072610	interleukin-12 secretion
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097029	mature dendritic cell differentiation
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000147	positive regulation of cell motility
GO:2000549	positive regulation of dendritic cell dendrite assembly