Version 5.4
Homo sapiens Protein: PAK1IP1
Summary
InnateDB Protein IDBP-61055.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK1IP1
Protein Name PAK1 interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000368887
InnateDB Gene IDBG-61053 (PAK1IP1)
Protein Structure
UniProt Annotation
Function Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. {ECO:0000269PubMed:11371639}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849}.
Disease Associations
Tissue Specificity Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus. {ECO:0000269PubMed:11371639}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008283 cell proliferation
GO:0009968 negative regulation of signal transduction
GO:0060021 palate development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWT1
PhosphoSite PhosphoSite-Q9NWT1
TrEMBL
UniProt Splice Variant
Entrez Gene 55003
UniGene Hs.310231
RefSeq NP_060376
HUGO HGNC:20882
OMIM 607811
CCDS CCDS34339
HPRD 07424
IMGT
EMBL AF283303 AK000631 AL358777 BC010907
GenPept AAH10907 AAK57477 BAA91296 CAI14002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca