InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL21

Summary

InnateDB Protein

IDBP-61076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL21

Protein Name

chemokine (C-C motif) ligand 21

Synonyms

6Ckine; CKb9; ECL; SCYA21; SLC; TCA4;

Species

Homo sapiens

Ensembl Protein

ENSP00000259607

InnateDB Gene

IDBG-61074 (CCL21)

Protein Structure

UniProt Annotation

Function

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0031732	CCR7 chemokine receptor binding
GO:0042379	chemokine receptor binding

Biological Process

GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002407	dendritic cell chemotaxis
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007267	cell-cell signaling
GO:0010560	positive regulation of glycoprotein biosynthetic process
GO:0030838	positive regulation of actin filament polymerization
GO:0031274	positive regulation of pseudopodium assembly
GO:0031295	T cell costimulation
GO:0031529	ruffle organization
GO:0032862	activation of Rho GTPase activity
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0034695	response to prostaglandin E
GO:0035759	mesangial cell-matrix adhesion
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048469	cell maturation
GO:0050921	positive regulation of chemotaxis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051491	positive regulation of filopodium assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0060326	cell chemotaxis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097026	dendritic cell dendrite assembly
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000147	positive regulation of cell motility
GO:2000406	positive regulation of T cell migration
GO:2000529	positive regulation of myeloid dendritic cell chemotaxis
GO:2000548	negative regulation of dendritic cell dendrite assembly