InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUT1

Summary

InnateDB Protein

IDBP-61102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT1

Protein Name

fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)

Synonyms

H; HH; HSC;

Species

Homo sapiens

Ensembl Protein

ENSP00000312021

InnateDB Gene

IDBG-61100 (FUT1)

Protein Structure

UniProt Annotation

Function

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity
GO:0008417	fucosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0036065	fucosylation
GO:0042355	L-fucose catabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002516 Glycosyl transferase, family 11

PFAM

PF01531

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-P19526

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB004859 AB004861 AB004862 AB004863 AY611628 AY780784 AY923051 BC074732 CH471177 EU081872 EU081873 FM180557 HM584610 KF906450 M35531 Z69587

GenPept

AAA52639 AAH74732 AAT42242 AAV51818 AAW82437 ABU75130 ABU75131 ADP20182 AHJ09661 BAA20556 BAA20558 BAA20559 BAA20560 CAA93435 CAQ81977 EAW52399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca