InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAV1

Summary

InnateDB Protein

IDBP-6111.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAV1

Protein Name

salvador homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324729

InnateDB Gene

IDBG-6109 (SAV1)

Protein Structure

UniProt Annotation

Function

Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269PubMed:16930133, ECO:0000269PubMed:19212654, ECO:0000269PubMed:21076410, ECO:0000269PubMed:21104395}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19212654}. Cytoplasm {ECO:0000269PubMed:19212654}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines. {ECO:0000269PubMed:19212654}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	78 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0007165	signal transduction
GO:0030216	keratinocyte differentiation
GO:0035329	hippo signaling
GO:0043065	positive regulation of apoptotic process
GO:0046620	regulation of organ growth
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060412	ventricular septum morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0060575	intestinal epithelial cell differentiation
GO:2000036	regulation of stem cell maintenance