InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRM6

Summary

InnateDB Protein

IDBP-61220.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM6

Protein Name

glutamate receptor, metabotropic 6

Synonyms

CSNB1B; GPRC1F; mGlu6; MGLUR6;

Species

Homo sapiens

Ensembl Protein

ENSP00000231188

InnateDB Gene

IDBG-61214 (GRM6)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269PubMed:23452348}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17405131}; Multi-pass membrane protein {ECO:0000269PubMed:17405131}. Endoplasmic reticulum membrane {ECO:0000269PubMed:17405131}; Multi-pass membrane protein {ECO:0000269PubMed:17405131}. Golgi apparatus membrane {ECO:0000269PubMed:17405131}; Multi-pass membrane protein {ECO:0000269PubMed:17405131}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.

Disease Associations

Night blindness, congenital stationary, 1B (CSNB1B) [MIM:257270]: A non-progressive retinal disorder characterized by impaired night vision. Congenital stationary night blindness type 1B is an autosomal recessive form associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced on response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. {ECO:0000269PubMed:15781871, ECO:0000269PubMed:17405131, ECO:0000269PubMed:23714322}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in melanocytes. {ECO:0000269PubMed:23452348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0009584	detection of visible light
GO:0050908	detection of light stimulus involved in visual perception
GO:0050953	sensory perception of light stimulus
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060041	retina development in camera-type eye
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0035841	new growing cell tip
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000112 GPCR, family 3, metabotropic glutamate receptor 6
IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR01056
PR00593
PR00248
PR01054

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15303