Homo sapiens Protein: RUVBL2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-61223.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | RUVBL2 | ||||||||||||||||||||||
Protein Name | RuvB-like 2 (E. coli) | ||||||||||||||||||||||
Synonyms | ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000221413 | ||||||||||||||||||||||
InnateDB Gene | IDBG-61221 (RUVBL2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. | ||||||||||||||||||||||
Subcellular Localization | Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed. Highly expressed in testis and thymus. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR003959
ATPase, AAA-type, core IPR007694 DNA helicase, DnaB-like, C-terminal IPR010339 TIP49, C-terminal IPR012340 Nucleic acid-binding, OB-fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00004
PF07724 PF13304 PF03796 PF06068 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART | |||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Y230 | ||||||||||||||||||||||
TrEMBL | X6R2L4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 10856 | ||||||||||||||||||||||
UniGene | Hs.515846 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:10475 | ||||||||||||||||||||||
OMIM | 604788 | ||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | 16070 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC008687 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||