InnateDB Protein
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IDBP-61284.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEPT4
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Protein Name
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septin 4
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Synonyms
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ARTS; BRADEION; CE5B3; H5; hCDCREL-2; MART; PNUTL2; SEP4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000321674
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InnateDB Gene
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IDBG-61280 (SEPT4)
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Protein Structure
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Function |
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. {ECO:0000250, ECO:0000269PubMed:11146656, ECO:0000269PubMed:15029247, ECO:0000269PubMed:15116257, ECO:0000269PubMed:15837787, ECO:0000269PubMed:9889007, ECO:0000305}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules. {ECO:0000269PubMed:11146656, ECO:0000269PubMed:15029247, ECO:0000269PubMed:15116257}.Isoform ARTS: Mitochondrion. Nucleus. Note=While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
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Disease Associations |
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Tissue Specificity |
Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets. {ECO:0000269PubMed:11146656, ECO:0000269PubMed:11167005, ECO:0000269PubMed:11511094, ECO:0000269PubMed:15116257, ECO:0000269PubMed:15915442, ECO:0000269PubMed:9889007}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000038
Cell division protein GTP binding
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00735
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43236
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PhosphoSite |
PhosphoSite-O43236
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5414
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UniGene |
Hs.711299
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RefSeq |
NP_004565
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HUGO |
HGNC:9165
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OMIM |
603696
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CCDS |
CCDS11610
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HPRD |
04738
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IMGT |
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EMBL |
AB008753
AF035811
AF073312
AF176379
AK094579
AK294094
AK301914
AK302146
AK315396
BC018056
CH471109
CR457111
D89278
U88829
U88870
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GenPept |
AAB88512
AAC25673
AAD00653
AAD00657
AAG45673
AAH18056
BAB46922
BAB70695
BAG37789
BAG52891
BAG57432
BAG63338
BAG63517
CAG33392
EAW94440
EAW94442
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