Version 5.4
Homo sapiens Protein: PLEKHA4
Summary
InnateDB Protein IDBP-61287.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHA4
Protein Name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263265
InnateDB Gene IDBG-61285 (PLEKHA4)
Protein Structure
UniProt Annotation
Function Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269PubMed:11001876}.
Subcellular Localization Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in melanoma. Detected at low levels in heart, skeletal muscle, kidney, liver and small intestine. {ECO:0000269PubMed:11001876}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005545 1-phosphatidylinositol binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4M7
PhosphoSite PhosphoSite-Q9H4M7
TrEMBL M0R2K5
UniProt Splice Variant
Entrez Gene 57664
UniGene Hs.9469
RefSeq NP_065955
HUGO HGNC:14339
OMIM 607769
CCDS CCDS12737
HPRD 09683
IMGT
EMBL AC026803 AY007233 BC024157 BC033832 BC064601
GenPept AAG01896 AAH24157 AAH33832 AAH64601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca