Version 5.4
Homo sapiens Protein: ZNF354C
Summary
InnateDB Protein IDBP-61297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF354C
Protein Name zinc finger protein 354C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000324064
InnateDB Gene IDBG-61295 (ZNF354C)
Protein Structure
UniProt Annotation
Function May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5'-CCACA-3' core sequence. May be involved in osteoblastic differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15555547}.
Disease Associations
Tissue Specificity Expressed in kidney and skeletal muscle. Very low expression in brain and heart. {ECO:0000269PubMed:15555547}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86Y25
PhosphoSite PhosphoSite-Q86Y25
TrEMBL Q9NT78
UniProt Splice Variant
Entrez Gene 30832
UniGene Hs.725370
RefSeq NP_055409
HUGO HGNC:16736
OMIM
CCDS CCDS4443
HPRD 15785
IMGT
EMBL AF395540 AF525463 AL137483 BC063312
GenPept AAH63312 AAM69676 AAO83897 CAB70764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca