Version 5.4
Homo sapiens Protein: PPP6R3
Summary
InnateDB Protein IDBP-61451.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP6R3
Protein Name protein phosphatase 6, regulatory subunit 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265636
InnateDB Gene IDBG-61449 (PPP6R3)
Protein Structure
UniProt Annotation
Function Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269PubMed:11401438, ECO:0000269PubMed:16769727}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes. {ECO:0000269PubMed:11401438, ECO:0000269PubMed:16769727}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR007587 SIT4 phosphatase-associated protein family
IPR016024 Armadillo-type fold
PFAM PF04499
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5H9R7
PhosphoSite PhosphoSite-Q5H9R7
TrEMBL Q9H880
UniProt Splice Variant
Entrez Gene 55291
UniGene Hs.706886
RefSeq NP_060782
HUGO HGNC:1173
OMIM 610879
CCDS CCDS8182
HPRD 10703
IMGT
EMBL AB046778 AF264779 AF264780 AK001920 AK023950 AK057250 AL834471 AP000807 AP001788 AP003096 BC007738 BC105933 BC105934 BC107599 CH471076 CR749815 CR933658 DQ111954
GenPept AAG36934 AAG36935 AAH07738 AAI05934 AAI05935 AAI07600 AAZ99639 BAA91978 BAB13384 BAB14737 BAB71396 CAD39130 CAH18675 CAI45957 EAW74709 EAW74711 EAW74712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca