InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELOVL2

Summary

InnateDB Protein

IDBP-61513.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELOVL2

Protein Name

ELOVL fatty acid elongase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346693

InnateDB Gene

IDBG-61511 (ELOVL2)

Protein Structure

UniProt Annotation

Function

Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. {ECO:0000269PubMed:12371743, ECO:0000269PubMed:20937905}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:20937905}; Multi-pass membrane protein {ECO:0000269PubMed:20937905}.

Disease Associations

Tissue Specificity

Liver and testis. {ECO:0000269PubMed:20937905}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009922	fatty acid elongase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0033559	unsaturated fatty acid metabolic process
GO:0034626	fatty acid elongation, polyunsaturated fatty acid
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0042761	very long-chain fatty acid biosynthetic process
GO:0043651	linoleic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process