Version 5.4
Homo sapiens Protein: P2RY13
Summary
InnateDB Protein IDBP-61537.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RY13
Protein Name purinergic receptor P2Y, G-protein coupled, 13
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000320376
InnateDB Gene IDBG-61535 (P2RY13)
Protein Structure
UniProt Annotation
Function Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. {ECO:0000269PubMed:11546776}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0008150 biological_process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005466 P2Y14 purinoceptor
IPR008109 P2Y13 purinoceptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
PFAM PF00001
PF10323
PRINTS PR00237
PR01655
PR01735
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BPV8
PhosphoSite PhosphoSite-Q9BPV8
TrEMBL
UniProt Splice Variant
Entrez Gene 53829
UniGene Hs.546396
RefSeq NP_795713
HUGO HGNC:4537
OMIM 606380
CCDS CCDS3158
HPRD 16210
IMGT
EMBL AB083597 AC024886 AF178982 AF295368 AF345565 AF406692 AF411113 AK313208 BC029363 BC041116 BC066887 CH471052
GenPept AAH29363 AAH41116 AAH66887 AAK01864 AAK18752 AAK29068 AAL01038 AAL26484 BAB89310 BAG36024 EAW78805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca