Homo sapiens Protein: NEDD9 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-61544.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NEDD9 | ||||||||||||||||||||||
Protein Name | neural precursor cell expressed, developmentally down-regulated 9 | ||||||||||||||||||||||
Synonyms | CAS-L; CAS2; CASL; CASS2; HEF1; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000368745 | ||||||||||||||||||||||
InnateDB Gene | IDBG-61538 (NEDD9) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001452
SH3 domain IPR011511 Variant SH3 domain |
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PFAM |
PF00018
PF14604 PF07653 |
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PRINTS |
PR00452
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PIRSF | |||||||||||||||||||||||
SMART |
SM00326
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q14511 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q14511 | ||||||||||||||||||||||
TrEMBL | D6RGD7 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4739 | ||||||||||||||||||||||
UniGene | Hs.737232 | ||||||||||||||||||||||
RefSeq | NP_892011 | ||||||||||||||||||||||
HUGO | HGNC:7733 | ||||||||||||||||||||||
OMIM | 602265 | ||||||||||||||||||||||
CCDS | CCDS34340 | ||||||||||||||||||||||
HPRD | 11888 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK292682 AL022098 AL136139 AL139807 AL512382 BC020686 BC040207 CH471087 L43821 U64317 | ||||||||||||||||||||||
GenPept | AAA98770 AAB53696 AAH20686 AAH40207 BAF85371 CAI21579 CAI21580 CAI22676 CAI22677 EAW55299 EAW55301 | ||||||||||||||||||||||