InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMP1

Summary

InnateDB Protein

IDBP-61668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMP1

Protein Name

TIMP metallopeptidase inhibitor 1

Synonyms

CLGI; EPA; EPO; HCI; TIMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000218388

InnateDB Gene

IDBG-61666 (TIMP1)

Protein Structure

UniProt Annotation

Function

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269PubMed:1420137, ECO:0000269PubMed:16917503, ECO:0000269PubMed:17050530, ECO:0000269PubMed:1730286, ECO:0000269PubMed:20545310, ECO:0000269PubMed:22427646, ECO:0000269PubMed:24635319, ECO:0000269PubMed:3839290, ECO:0000269PubMed:3903517, ECO:0000269PubMed:8541540, ECO:0000269PubMed:8576151, ECO:0000269PubMed:9065415}.

Subcellular Localization

Secreted {ECO:0000269PubMed:1730286, ECO:0000269PubMed:24635319, ECO:0000269PubMed:3010309, ECO:0000269PubMed:3839290, ECO:0000269PubMed:3903517, ECO:0000269PubMed:8541540}.

Disease Associations

Tissue Specificity

Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269PubMed:1730286}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0001775	cell activation
GO:0002576	platelet degranulation
GO:0007568	aging
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0010033	response to organic substance
GO:0010951	negative regulation of endopeptidase activity
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0048553	negative regulation of metalloenzyme activity
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:1901164	negative regulation of trophoblast cell migration
GO:2001044	regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM

PF00965

PRINTS

PIRSF

SMART

SM00206

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01033