Version 5.4
Homo sapiens Protein: LHB
Summary
InnateDB Protein IDBP-61722.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHB
Protein Name luteinizing hormone beta polypeptide
Synonyms CGB4; hLHB; LSH-B;
Species Homo sapiens
Ensembl Protein ENSP00000221421
InnateDB Gene IDBG-61720 (LHB)
Protein Structure
UniProt Annotation
Function Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Subcellular Localization Secreted.
Disease Associations Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism. {ECO:0000269PubMed:1727547}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Pituitary gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0006701 progesterone biosynthetic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008584 male gonad development
GO:0016486 peptide hormone processing
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001545 Gonadotropin, beta subunit
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR029034 Cystine-knot cytokine
PFAM PF00007
PRINTS
PIRSF
SMART SM00068
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01229
PhosphoSite PhosphoSite-
TrEMBL Q8WXL0
UniProt Splice Variant
Entrez Gene 3972
UniGene
RefSeq NP_000885
HUGO HGNC:6584
OMIM 152780
CCDS CCDS12748
HPRD 01072
IMGT
EMBL AF397591 S71273 X00264
GenPept AAD14960 AAL69719 CAA25067

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca