InnateDB Protein
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IDBP-61737.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF34
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Protein Name
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ring finger protein 34
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355137
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InnateDB Gene
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IDBG-61735 (RNF34)
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Protein Structure
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Function |
Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate. {ECO:0000269PubMed:12118383, ECO:0000269PubMed:15069192, ECO:0000269PubMed:15897238}.
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Subcellular Localization |
Nucleus speckle. Endomembrane system; Peripheral membrane protein.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269PubMed:12118383, ECO:0000269PubMed:15069192}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0016567
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protein ubiquitination
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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GO:2001271
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negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q969K3
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PhosphoSite |
PhosphoSite-Q969K3
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TrEMBL |
G3V5F1
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UniProt Splice Variant |
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Entrez Gene |
80196
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UniGene |
Hs.657765
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RefSeq |
NP_079402
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HUGO |
HGNC:17297
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OMIM |
608299
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CCDS |
CCDS31915
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HPRD |
10509
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IMGT |
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EMBL |
AB084914
AC048337
AC073650
AF306709
AK025439
AK304366
AY098934
BC007826
BT007283
CR457342
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GenPept |
AAH07826
AAK51328
AAM29180
AAP35947
BAB15132
BAC11802
BAH14169
CAG33623
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