InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPCN2

Summary

InnateDB Protein

IDBP-61774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPCN2

Protein Name

two pore segment channel 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000294309

InnateDB Gene

IDBG-61770 (TPCN2)

Protein Structure

UniProt Annotation

Function

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269PubMed:19387438, ECO:0000269PubMed:19620632}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269PubMed:19387438}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0072345	NAADP-sensitive calcium-release channel activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane