Version 5.4
Homo sapiens Protein: NINL
Summary
InnateDB Protein IDBP-61837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NINL
Protein Name ninein-like
Synonyms dJ691N24.1; NLP;
Species Homo sapiens
Ensembl Protein ENSP00000278886
InnateDB Gene IDBG-61835 (NINL)
Protein Structure
UniProt Annotation
Function Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269PubMed:12852856, ECO:0000269PubMed:16254247, ECO:0000269PubMed:18538832}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein- dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm.
Disease Associations
Tissue Specificity Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina. {ECO:0000269PubMed:17403670, ECO:0000269PubMed:18826961}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
Cellular Component
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2I6
PhosphoSite PhosphoSite-Q9Y2I6
TrEMBL
UniProt Splice Variant
Entrez Gene 22981
UniGene Hs.721283
RefSeq NP_079452
HUGO HGNC:29163
OMIM 609580
CCDS CCDS33452
HPRD 11120
IMGT
EMBL AB023197 AK293991 AL031672 AL161802 BC036380 EU718622
GenPept AAH36380 ACE78295 BAA76824 BAH11644 CAI43018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca