InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMAN2L

Summary

InnateDB Protein

IDBP-61846.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMAN2L

Protein Name

lectin, mannose-binding 2-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366280

InnateDB Gene

IDBG-61842 (LMAN2L)

Protein Structure

UniProt Annotation

Function

May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. {ECO:0000269PubMed:12878160}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.

Disease Associations

Tissue Specificity

Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung. {ECO:0000269PubMed:12878160}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005537	mannose binding
GO:0046872	metal ion binding

Biological Process

GO:0006457	protein folding
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030134	ER to Golgi transport vesicle