InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHACTR1

Summary

InnateDB Protein

IDBP-61962.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHACTR1

Protein Name

phosphatase and actin regulator 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368655

InnateDB Gene

IDBG-61960 (PHACTR1)

Protein Structure

UniProt Annotation

Function

Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival. {ECO:0000269PubMed:21798305, ECO:0000269PubMed:21939755}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in umbilical vein endothelial cells. {ECO:0000269PubMed:21939755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004864	protein phosphatase inhibitor activity

Biological Process

GO:0031032	actomyosin structure organization
GO:0031532	actin cytoskeleton reorganization
GO:0043086	negative regulation of catalytic activity
GO:0043149	stress fiber assembly
GO:0048870	cell motility