Version 5.4
Mus musculus Protein: Lsm5
Summary
InnateDB Protein IDBP-619724.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsm5
Protein Name LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms 2010208O10Rik; 2310034K10Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000126565
InnateDB Gene IDBG-604785 (Lsm5)
Protein Structure
UniProt Annotation
Function Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex in vitro (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005681 spliceosomal complex
Protein Structure and Domains
PDB ID MGI:1913623
InterPro IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
PFAM PF01423
PRINTS
PIRSF
SMART SM00651
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62322
PhosphoSite PhosphoSite-P62322
TrEMBL H3BKC5
UniProt Splice Variant
Entrez Gene 66373
UniGene Mm.490925
RefSeq NP_079796
MGI ID
MGI Symbol Lsm5
OMIM
CCDS CCDS51788
HPRD
IMGT
EMBL AC115003 AK009617 AK011218 BC048459 BC061085 BC132626 BC132628
GenPept AAH48459 AAH61085 AAI32627 AAI32629 BAB26394 BAB27475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca