InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm3a

Summary

InnateDB Protein

IDBP-619801.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm3a

Protein Name

lysine (K)-specific demethylase 3A

Synonyms

1700105C21Rik; C230043E16Rik; JHDM2a; Jmjd1; Jmjd1a; KDM2A; TGSA; Tsga;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128789

InnateDB Gene

IDBG-155780 (Kdm3a)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000250, ECO:0000269PubMed:17943087, ECO:0000269PubMed:19194461}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17943087}. Nucleus {ECO:0000269PubMed:17943087}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa.

Disease Associations

Tissue Specificity

Highly expressed in testis (at protein level). Also expressed at high levels in tissues responsive to sympathetic nerve activity such as brown adipose tissue and skeletal muscle. {ECO:0000269PubMed:17943087}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0050681	androgen receptor binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0007290	spermatid nucleus elongation
GO:0009755	hormone-mediated signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0033169	histone H3-K9 demethylation
GO:0036123	histone H3-K9 dimethylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046293	formaldehyde biosynthetic process
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0055114	oxidation-reduction process