Version 5.4
Homo sapiens Protein: FGF19
Summary
InnateDB Protein IDBP-61982.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF19
Protein Name fibroblast growth factor 19
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000294312
InnateDB Gene IDBG-61980 (FGF19)
Protein Structure
UniProt Annotation
Function Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269PubMed:12815072, ECO:0000269PubMed:16597617, ECO:0000269PubMed:17623664, ECO:0000269PubMed:19085950}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in fetal brain, cartilage, retina, and adult gall bladder. {ECO:0000269PubMed:10525310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001755 neural crest cell migration
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0046326 positive regulation of glucose import
GO:0046330 positive regulation of JNK cascade
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070858 negative regulation of bile acid biosynthetic process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002209 Fibroblast growth factor family
IPR008996 Cytokine, IL-1-like
IPR028142 IL-1 family/FGF family
PFAM
PRINTS PR00263
PR00262
PIRSF
SMART SM00442
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95750
PhosphoSite PhosphoSite-O95750
TrEMBL
UniProt Splice Variant
Entrez Gene 9965
UniGene Hs.249200
RefSeq NP_005108
HUGO HGNC:3675
OMIM 603891
CCDS CCDS8193
HPRD 04868
IMGT
EMBL AB018122 AF110400 AY358302 BC017664 BT006729
GenPept AAD45973 AAH17664 AAP35375 AAQ88669 BAA75500

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca