Version 5.4
Mus musculus Protein: Men1
Summary
InnateDB Protein IDBP-619863.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Men1
Protein Name multiple endocrine neoplasia 1
Synonyms AW045611;
Species Mus musculus
Ensembl Protein ENSMUSP00000133085
InnateDB Gene IDBG-135755 (Men1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001503 ossification
GO:0001776 leukocyte homeostasis
GO:0002051 osteoblast fate commitment
GO:0002076 osteoblast development
GO:0006338 chromatin remodeling
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0016571 histone methylation
GO:0030097 hemopoiesis
GO:0031062 positive regulation of histone methylation
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046621 negative regulation of organ growth
GO:0048704 embryonic skeletal system morphogenesis
GO:0051781 positive regulation of cell division
GO:0060021 palate development
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035097 histone methyltransferase complex
Protein Structure and Domains
PDB ID MGI:1316736
InterPro IPR007747 Menin
PFAM PF05053
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PV51
UniProt Splice Variant
Entrez Gene 17283
UniGene Mm.453222
RefSeq
MGI ID
MGI Symbol Men1
OMIM
CCDS
HPRD
IMGT
EMBL AC127556
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca