Version 5.4
Mus musculus Protein: Cybasc3
Summary
InnateDB Protein IDBP-619927.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cybasc3
Protein Name cytochrome b, ascorbate dependent 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000130680
InnateDB Gene IDBG-144393 (Cybasc3)
Protein Structure
UniProt Annotation
Function Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor. {ECO:0000269PubMed:16911521}.
Subcellular Localization Late endosome membrane {ECO:0000269PubMed:16996694}; Multi-pass membrane protein {ECO:0000269PubMed:16996694}. Lysosome membrane {ECO:0000269PubMed:16996694}; Multi-pass membrane protein {ECO:0000269PubMed:16996694}.
Disease Associations
Tissue Specificity Present in lung, spleen, thymus and testis. Present at low level in brain, heart, liver and kidney. Expressed in the alveolar macrophages of the lung, in the white pulp of the spleen, widespread in the thymus, and in the Sertoli cells of the testis (at protein level). {ECO:0000269PubMed:16996694}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID MGI:2686925
InterPro IPR004877 Cytochrome b561, eukaryote
IPR006593 Cytochrome b561/ferric reductase transmembrane
PFAM PF03188
PRINTS
PIRSF
SMART SM00665
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1H1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 225912
UniGene
RefSeq NP_958739
MGI ID
MGI Symbol Cyb561a3
OMIM
CCDS CCDS29582
HPRD
IMGT
EMBL AK040692 AK139533 AK160179 AK168841 AK169729 AK170911 AK172638 BC065078
GenPept AAH65078 BAE20585 BAE24053 BAE35677 BAE40664 BAE41333 BAE42109 BAE43109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca