Version 5.4
Mus musculus Protein: Zfp143
Summary
InnateDB Protein IDBP-619990.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp143
Protein Name zinc finger protein 143
Synonyms AA959806; AU015869; D7Ertd805e; KRAB14; pHZ-1; SBF; Staf; Zfp79; Zfp80-rs1; Znf143;
Species Mus musculus
Ensembl Protein ENSMUSP00000126015
InnateDB Gene IDBG-206459 (Zfp143)
Protein Structure
UniProt Annotation
Function Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1277969
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70230
PhosphoSite PhosphoSite-O70230
TrEMBL
UniProt Splice Variant
Entrez Gene 20841
UniGene Mm.10815
RefSeq
MGI ID
MGI Symbol Zfp143
OMIM
CCDS
HPRD
IMGT
EMBL AF011758 AJ278435 AK028056 AK029078 AK029926 BC037658
GenPept AAC16899 AAH37658 BAC25726 BAC26281 BAC26682 CAC17144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca