InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hk2

Summary

InnateDB Protein

IDBP-620062.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hk2

Protein Name

hexokinase 2

Synonyms

AI642394; HKII;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125986

InnateDB Gene

IDBG-159047 (Hk2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0008865	fructokinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0007595	lactation
GO:0008637	apoptotic mitochondrial changes
GO:0046324	regulation of glucose import
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1315197

InterPro

IPR001312 Hexokinase
IPR022672 Hexokinase, N-terminal
IPR022673 Hexokinase, C-terminal

PFAM

PF00349
PF03727

PRINTS

PR00475

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9Q9M6

UniProt Splice Variant

Entrez Gene

15277

UniGene

Mm.469167

RefSeq

MGI ID

MGI Symbol

Hk2

OMIM

CCDS

HPRD

IMGT

EMBL

AC116811

GenPept