InnateDB Protein
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IDBP-620084.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Etv3
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Protein Name
|
ets variant gene 3
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Synonyms
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AI414410; METS; Pe1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000127419
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InnateDB Gene
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IDBG-157285 (Etv3)
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Protein Structure
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Function |
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269PubMed:10913304, ECO:0000269PubMed:12007404}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00237}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030154
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cell differentiation
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Cellular Component |
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PDB ID |
MGI:1350926
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R4Z4
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PhosphoSite |
PhosphoSite-Q8R4Z4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27049
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UniGene |
Mm.446456
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RefSeq |
NP_036181
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MGI ID |
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MGI Symbol |
Etv3
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OMIM |
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CCDS |
CCDS17453
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HPRD |
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IMGT |
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EMBL |
AC139241
AF156530
AF218539
AY274927
BC078636
CH466547
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GenPept |
AAF09185
AAH78636
AAK56845
AAQ18663
EDL15354
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