InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEFA5

Summary

InnateDB Protein

IDBP-6201.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEFA5

Protein Name

defensin, alpha 5, Paneth cell-specific

Synonyms

DEF5; HD-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000329890

InnateDB Gene

IDBG-6199 (DEFA5)

Protein Structure

UniProt Annotation

Function

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. {ECO:0000269PubMed:12021776, ECO:0000269PubMed:15616305, ECO:0000269PubMed:17088326}.

Subcellular Localization

Secreted {ECO:0000269PubMed:12021776}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269PubMed:12021776}. Note=Peptides HD5(20-94), HD5(23- 94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.

Disease Associations

Tissue Specificity

Paneth cells of the small intestine (at protein level). {ECO:0000269PubMed:12021776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006952	defense response
GO:0019731	antibacterial humoral response
GO:0031640	killing of cells of other organism
GO:0045087	innate immune response (InnateDB)
GO:0050832	defense response to fungus