Version 5.4
Mus musculus Protein: F13a1
Summary
InnateDB Protein IDBP-620159.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F13a1
Protein Name coagulation factor XIII, A1 subunit
Synonyms 1200014I03Rik; AI462306; F13a;
Species Mus musculus
Ensembl Protein ENSMUSP00000128316
InnateDB Gene IDBG-145103 (F13a1)
Protein Structure
UniProt Annotation
Function Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Cytoplasmic in most tissues, but also secreted in the blood plasma. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0007596 blood coagulation
GO:0018149 peptide cross-linking
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1921395
InterPro IPR001102 Transglutaminase, N-terminal
IPR002931 Transglutaminase-like
IPR008958 Transglutaminase, C-terminal
IPR014756 Immunoglobulin E-set
PFAM PF00868
PF01841
PF00927
PRINTS
PIRSF
SMART SM00460
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BH61
PhosphoSite PhosphoSite-
TrEMBL Q3TQH1
UniProt Splice Variant
Entrez Gene 74145
UniGene Mm.235105
RefSeq NP_001159863
MGI ID
MGI Symbol F13a1
OMIM
CCDS CCDS26456
HPRD
IMGT
EMBL AK036403 AK049092 AK163591 AK165311 BC040274
GenPept AAH40274 BAC29414 BAC33539 BAE37411 BAE38130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca