InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab2b

Summary

InnateDB Protein

IDBP-620161.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab2b

Protein Name

RAB2B, member RAS oncogene family

Synonyms

1500012D09Rik; 4930528G15Rik; A230002G14; D530043M21Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131145

InnateDB Gene

IDBG-158519 (Rab2b)

Protein Structure

UniProt Annotation

Function

Required for protein transport from the endoplasmic reticulum to the Golgi complex. {ECO:0000305}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0045921	positive regulation of exocytosis

Cellular Component

GO:0000139	Golgi membrane
GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1923588

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt