InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF4

Summary

InnateDB Protein

IDBP-62018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF4

Protein Name

fibroblast growth factor 4

Synonyms

HBGF-4; HST; HST-1; HSTF1; K-FGF; KFGF;

Species

Homo sapiens

Ensembl Protein

ENSP00000168712

InnateDB Gene

IDBG-62016 (FGF4)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. {ECO:0000269PubMed:8663044}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001502	cartilage condensation
GO:0001934	positive regulation of protein phosphorylation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010463	mesenchymal cell proliferation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0019827	stem cell maintenance
GO:0030326	embryonic limb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051781	positive regulation of cell division
GO:0060363	cranial suture morphogenesis
GO:0060561	apoptotic process involved in morphogenesis
GO:0060591	chondroblast differentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade