InnateDB Protein
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IDBP-620189.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Psmb11
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Protein Name
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proteasome (prosome, macropain) subunit, beta type, 11
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Synonyms
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5830406J20Rik; beta5t;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000132140
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InnateDB Gene
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IDBG-161730 (Psmb11)
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Protein Structure
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Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells. {ECO:0000269PubMed:17540904}.
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Subcellular Localization |
Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed exclusively in cortical thymic epithelial cells. {ECO:0000269PubMed:17540904}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004298
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threonine-type endopeptidase activity
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Biological Process |
GO:0051603
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proteolysis involved in cellular protein catabolic process
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Cellular Component |
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PDB ID |
MGI:1921152
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InterPro |
IPR000243
Peptidase T1A, proteasome beta-subunit
IPR001353
Proteasome, subunit alpha/beta
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF00227
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PRINTS |
PR00141
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BG41
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PhosphoSite |
PhosphoSite-Q8BG41
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
73902
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UniGene |
Mm.409541
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RefSeq |
NP_780413
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MGI ID |
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MGI Symbol |
Psmb11
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OMIM |
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CCDS |
CCDS49491
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HPRD |
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IMGT |
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EMBL |
AB299436
AK037368
AK041393
AK162727
BC117732
BC117733
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GenPept |
AAI17733
AAI17734
BAC29796
BAC30929
BAE37039
BAF63539
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