Version 5.4
Mus musculus Protein: Psmb11
Summary
InnateDB Protein IDBP-620189.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb11
Protein Name proteasome (prosome, macropain) subunit, beta type, 11
Synonyms 5830406J20Rik; beta5t;
Species Mus musculus
Ensembl Protein ENSMUSP00000132140
InnateDB Gene IDBG-161730 (Psmb11)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells. {ECO:0000269PubMed:17540904}.
Subcellular Localization Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed exclusively in cortical thymic epithelial cells. {ECO:0000269PubMed:17540904}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
Protein Structure and Domains
PDB ID MGI:1921152
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 Proteasome, subunit alpha/beta
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF00227
PRINTS PR00141
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG41
PhosphoSite PhosphoSite-Q8BG41
TrEMBL
UniProt Splice Variant
Entrez Gene 73902
UniGene Mm.409541
RefSeq NP_780413
MGI ID
MGI Symbol Psmb11
OMIM
CCDS CCDS49491
HPRD
IMGT
EMBL AB299436 AK037368 AK041393 AK162727 BC117732 BC117733
GenPept AAI17733 AAI17734 BAC29796 BAC30929 BAE37039 BAF63539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca