Version 5.4
Mus musculus Protein: Psme1
Summary
InnateDB Protein IDBP-620240.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psme1
Protein Name proteasome (prosome, macropain) 28 subunit, alpha
Synonyms AW413925; PA28a;
Species Mus musculus
Ensembl Protein ENSMUSP00000134735
InnateDB Gene IDBG-164103 (Psme1)
Protein Structure
UniProt Annotation
Function Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0061133 endopeptidase activator activity
Biological Process
GO:0010950 positive regulation of endopeptidase activity
GO:0019884 antigen processing and presentation of exogenous antigen
Cellular Component
GO:0008537 proteasome activator complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1096367
InterPro IPR003185 Proteasome activator pa28, N-terminal domain
IPR003186 Proteasome activator pa28, C-terminal domain
IPR009077 Proteasome activator pa28
PFAM PF02251
PF02252
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97371
PhosphoSite PhosphoSite-P97371
TrEMBL Q5HZK3
UniProt Splice Variant
Entrez Gene 19186
UniGene Mm.830
RefSeq NP_035319
MGI ID
MGI Symbol Psme1
OMIM
CCDS CCDS36931
HPRD
IMGT
EMBL AB007136 AB053120 AC174678 AK008514 AK019390 AK150708 AK150975 BC088981 CH466535 D87909 U60328
GenPept AAC53295 AAH88981 BAA22039 BAA28835 BAB25712 BAB31696 BAB47403 BAE29786 BAE30004 EDL36283

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca