InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nedd8

Summary

InnateDB Protein

IDBP-620264.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nedd8

Protein Name

neural precursor cell expressed, developmentally down-regulated gene 8

Synonyms

Rub1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130492

InnateDB Gene

IDBG-165173 (Nedd8)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. {ECO:0000269PubMed:11696557}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12215427}. Note=Mainly nuclear.

Disease Associations

Tissue Specificity

Ubiquitously expressed (at protein level). {ECO:0000269PubMed:15183309, ECO:0000269PubMed:8395831}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 341 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	341 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008104	protein localization
GO:0014070	response to organic cyclic compound
GO:0045116	protein neddylation