InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rabggta

Summary

InnateDB Protein

IDBP-620269.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rabggta

Protein Name

Rab geranylgeranyl transferase, a subunit

Synonyms

gm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128668

InnateDB Gene

IDBG-165484 (Rabggta)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269PubMed:10737774}.

Subcellular Localization

Disease Associations

Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents. {ECO:0000269PubMed:10737774}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004663	Rab geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008318	protein prenyltransferase activity
GO:0017137	Rab GTPase binding

Biological Process

GO:0018342	protein prenylation
GO:0018344	protein geranylgeranylation

Cellular Component

GO:0005968

Rab-protein geranylgeranyltransferase complex

Protein Structure and Domains

PDB ID

MGI:1860443

InterPro

IPR001611 Leucine-rich repeat
IPR002088 Protein prenyltransferase, alpha subunit
IPR009087 Rab geranylgeranyltransferase, alpha subunit, insert-domain

PFAM

PF00560
PF13504
PF13855
PF01239
PF07711

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHK4

PhosphoSite