Version 5.4
Mus musculus Protein: Rhbg
Summary
InnateDB Protein IDBP-620320.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhbg
Protein Name Rhesus blood group-associated B glycoprotein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000130767
InnateDB Gene IDBG-160032 (Rhbg)
Protein Structure
UniProt Annotation
Function Functions as a specific ammonium transporter. {ECO:0000269PubMed:15353405, ECO:0000269PubMed:16131648}.
Subcellular Localization Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in kidney by connecting segments and collecting tubules. Also expressed in liver by perivenous hepatocytes. Expressed in the forestomach and the fundus of the stomach. Expressed in duodenum, jejunum, ileum and colon at the level of villous (at protein level). Specifically expressed in kidney where it is restricted to the epithelial linings of the convoluted tubules and the loop of Henle. Also detected in ovary. Expressed by hepatocytes and dermal hair follicles and papillae. {ECO:0000269PubMed:11024028, ECO:0000269PubMed:12388412, ECO:0000269PubMed:12730882, ECO:0000269PubMed:15576624}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008519 ammonium transmembrane transporter activity
GO:0030506 ankyrin binding
Biological Process
GO:0015696 ammonium transport
GO:0070634 transepithelial ammonium transport
GO:0072488 ammonium transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1927379
InterPro IPR002229 Blood group Rhesus C/E/D polypeptide
IPR024041 Ammonium transporter AmtB-like domain
PFAM PF00909
PRINTS PR00342
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BUX5
PhosphoSite PhosphoSite-
TrEMBL E9Q2A2
UniProt Splice Variant
Entrez Gene 58176
UniGene Mm.103777
RefSeq NP_067350
MGI ID
MGI Symbol Rhbg
OMIM
CCDS CCDS17466
HPRD
IMGT
EMBL AC044864 AF193808 AK081882 AY254685 BC029236
GenPept AAF19371 AAH29236 AAP81167 BAC38359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca