InnateDB Protein
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IDBP-620430.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdca2
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Protein Name
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cell division cycle associated 2
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Synonyms
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2610311M19Rik; AI586158;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000127571
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InnateDB Gene
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IDBG-176041 (Cdca2)
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Protein Structure
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Function |
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919787
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14B71
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PhosphoSite |
PhosphoSite-Q14B71
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TrEMBL |
D3Z5P7
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UniProt Splice Variant |
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Entrez Gene |
108912
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UniGene |
Mm.454066
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RefSeq |
NP_001103632
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MGI ID |
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MGI Symbol |
Cdca2
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OMIM |
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CCDS |
CCDS36962
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HPRD |
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IMGT |
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EMBL |
AC093020
AK031083
AK031313
BC116298
BC116299
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GenPept |
AAI16299
AAI16300
BAC27245
BAC27343
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