InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sumf2

Summary

InnateDB Protein

IDBP-620432.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sumf2

Protein Name

sulfatase modifying factor 2

Synonyms

2610040F05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126036

InnateDB Gene

IDBG-202045 (Sumf2)

Protein Structure

UniProt Annotation

Function

Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:1915152

InterPro

IPR005532 Formylglycine-generating sulphatase enzyme domain
IPR016187 C-type lectin fold

PFAM

PF03781

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BPG6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

67902

UniGene

Mm.103546

RefSeq

NP_080721

MGI ID

MGI Symbol

Sumf2

OMIM

CCDS

CCDS19700

HPRD

IMGT

EMBL

AK076022 AK138300 AK157784 CH466529

GenPept

BAC36127 BAE23615 BAE34197 EDL19497