InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp27b1

Summary

InnateDB Protein

IDBP-620443.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp27b1

Protein Name

cytochrome P450, family 27, subfamily b, polypeptide 1

Synonyms

Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr; Vdd1; Vddr; VddrI; Vdr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130005

InnateDB Gene

IDBG-194013 (Cyp27b1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.

Subcellular Localization

Mitochondrion membrane.

Disease Associations

Tissue Specificity

Kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004498	calcidiol 1-monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006816	calcium ion transport
GO:0008285	negative regulation of cell proliferation
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
GO:0010980	positive regulation of vitamin D 24-hydroxylase activity
GO:0030282	bone mineralization
GO:0030308	negative regulation of cell growth
GO:0030500	regulation of bone mineralization
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0034341	response to interferon-gamma
GO:0036378	calcitriol biosynthetic process from calciol
GO:0042359	vitamin D metabolic process
GO:0042369	vitamin D catabolic process
GO:0043627	response to estrogen
GO:0045618	positive regulation of keratinocyte differentiation
GO:0046697	decidualization
GO:0055074	calcium ion homeostasis
GO:0055114	oxidation-reduction process
GO:0070314	G1 to G0 transition
GO:0070564	positive regulation of vitamin D receptor signaling pathway