Version 5.4
Mus musculus Protein: Iars
Summary
InnateDB Protein IDBP-620459.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iars
Protein Name isoleucine-tRNA synthetase
Synonyms 2510016L12Rik; AI327140; AU044614; E430001P04Rik; ILRS;
Species Mus musculus
Ensembl Protein ENSMUSP00000132082
InnateDB Gene IDBG-151359 (Iars)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2145219
InterPro IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR002301 Isoleucine-tRNA ligase
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase
PFAM PF00133
PF08264
PF09334
PRINTS PR00984
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BU30
PhosphoSite PhosphoSite-Q8BU30
TrEMBL E9Q866
UniProt Splice Variant
Entrez Gene 105148
UniGene Mm.21118
RefSeq NP_742012
MGI ID
MGI Symbol Iars
OMIM
CCDS CCDS36659
HPRD
IMGT
EMBL AC125070 AK087992 AK133856 BC067029 CH466546
GenPept AAH67029 BAC40081 BAE21890 EDL41088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca