InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Iars

Summary

InnateDB Protein

IDBP-620467.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Iars

Protein Name

isoleucine-tRNA synthetase

Synonyms

2510016L12Rik; AI327140; AU044614; E430001P04Rik; ILRS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126806

InnateDB Gene

IDBG-151359 (Iars)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004822	isoleucine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006428	isoleucyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2145219

InterPro

IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR002301 Isoleucine-tRNA ligase
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase

PFAM

PF00133
PF08264
PF09334

PRINTS

PR00984

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BU30