Homo sapiens Protein: KCNA7 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-62064.5 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | KCNA7 | ||||||||||||
Protein Name | potassium voltage-gated channel, shaker-related subfamily, member 7 | ||||||||||||
Synonyms | HAK6; KV1.7; | ||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Protein | ENSP00000221444 | ||||||||||||
InnateDB Gene | IDBG-62062 (KCNA7) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Highly expressed in skeletal muscle, heart and kidney. {ECO:0000269PubMed:11368907, ECO:0000269PubMed:11896454}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR000210
BTB/POZ-like IPR003091 Potassium channel IPR003131 Potassium channel tetramerisation-type BTB domain IPR003968 Potassium channel, voltage dependent, Kv IPR003972 Potassium channel, voltage dependent, Kv1 IPR005821 Ion transport domain IPR011333 BTB/POZ fold IPR013099 Two pore domain potassium channel domain |
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PFAM |
PF02214
PF00520 PF07885 |
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PRINTS |
PR00169
PR01491 PR01496 |
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PIRSF | |||||||||||||
SMART |
SM00225
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q96RP8 | ||||||||||||
PhosphoSite | PhosphoSite-Q96RP8 | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 3743 | ||||||||||||
UniGene | Hs.306973 | ||||||||||||
RefSeq | NP_114092 | ||||||||||||
HUGO | HGNC:6226 | ||||||||||||
OMIM | 176268 | ||||||||||||
CCDS | CCDS12755 | ||||||||||||
HPRD | 01445 | ||||||||||||
IMGT | |||||||||||||
EMBL | AF315818 AJ310479 AY779768 | ||||||||||||
GenPept | AAK63002 AAX11186 CAC29065 | ||||||||||||