InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema4a

Summary

InnateDB Protein

IDBP-620644.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema4a

Protein Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

Synonyms

AI132332; Semab; SemB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128887

InnateDB Gene

IDBG-160873 (Sema4a)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. {ECO:0000269PubMed:12374982, ECO:0000269PubMed:15780988, ECO:0000269PubMed:17318185, ECO:0000269PubMed:20043131}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12374982, ECO:0000269PubMed:15780988, ECO:0000269PubMed:17318185, ECO:0000269PubMed:20043131}; Single-pass type I membrane protein {ECO:0000269PubMed:12374982, ECO:0000269PubMed:15780988, ECO:0000269PubMed:17318185, ECO:0000269PubMed:20043131}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0002292	T cell differentiation involved in immune response
GO:0007275	multicellular organismal development
GO:0007409	axonogenesis
GO:0008360	regulation of cell shape
GO:0010594	regulation of endothelial cell migration
GO:0016525	negative regulation of angiogenesis
GO:0045063	T-helper 1 cell differentiation
GO:0071526	semaphorin-plexin signaling pathway