InnateDB Protein
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IDBP-620674.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wibg
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Protein Name
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within bgcn homolog (Drosophila)
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Synonyms
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A030010B05Rik; Pym;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000129789
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InnateDB Gene
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IDBG-198370 (Wibg)
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Protein Structure
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Function |
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
20 [view]
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Molecular Function |
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Biological Process |
GO:0000184
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nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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GO:0045727
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positive regulation of translation
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Cellular Component |
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PDB ID |
MGI:1925678
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InterPro |
IPR015362
Exon junction complex, Pym
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PFAM |
PF09282
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CHP5
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PhosphoSite |
PhosphoSite-Q8CHP5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
78428
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UniGene |
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RefSeq |
NP_084376
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MGI ID |
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MGI Symbol |
Wibg
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OMIM |
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CCDS |
CCDS48729
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HPRD |
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IMGT |
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EMBL |
AJ459407
BC049647
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GenPept |
AAH49647
CAD30678
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