InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Park2

Summary

InnateDB Protein

IDBP-620718.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Park2

Protein Name

Parkinson disease (autosomal recessive, juvenile) 2, parkin

Synonyms

PRKN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127455

InnateDB Gene

IDBG-136351 (Park2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	124 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0001964	startle response
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0008344	adult locomotory behavior
GO:0016567	protein ubiquitination
GO:0019538	protein metabolic process
GO:0035249	synaptic transmission, glutamatergic
GO:0042415	norepinephrine metabolic process
GO:0042417	dopamine metabolic process
GO:0046928	regulation of neurotransmitter secretion
GO:0050804	regulation of synaptic transmission
GO:0051583	dopamine uptake involved in synaptic transmission

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0043005	neuron projection
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1355296

InterPro

IPR000626 Ubiquitin-like
IPR003977 E3 ubiquitin-protein ligase parkin
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF11976

PRINTS

PR01475
PR00348

PIRSF

PIRSF037880

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References