Mus musculus Protein: Park2
Summary
InnateDB Protein IDBP-620718.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Park2
Protein Name Parkinson disease (autosomal recessive, juvenile) 2, parkin
Synonyms PRKN;
Species Mus musculus
Ensembl Protein ENSMUSP00000127455
InnateDB Gene IDBG-136351 (Park2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 124 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0001963 synaptic transmission, dopaminergic
GO:0001964 startle response
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008344 adult locomotory behavior
GO:0016567 protein ubiquitination
GO:0019538 protein metabolic process
GO:0035249 synaptic transmission, glutamatergic
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0046928 regulation of neurotransmitter secretion
GO:0050804 regulation of synaptic transmission
GO:0051583 dopamine uptake involved in synaptic transmission
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043005 neuron projection
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1355296
InterPro IPR000626 Ubiquitin-like
IPR003977 E3 ubiquitin-protein ligase parkin
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain
PFAM PF00240
PF14560
PF11976
PRINTS PR01475
PR00348
PIRSF PIRSF037880
SMART SM00213
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q7TPF8
UniProt Splice Variant
Entrez Gene 50873
UniGene
RefSeq XP_006523401
MGI ID
MGI Symbol Park2
OMIM
CCDS
HPRD
IMGT
EMBL AC091254 AC091484 AC091777 AC093450 AC113265 AC118545 AC122259
GenPept AAP94053 AAP94054