InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gcnt1

Summary

InnateDB Protein

IDBP-620800.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gcnt1

Protein Name

glucosaminyl (N-acetyl) transferase 1, core 2

Synonyms

5630400D21Rik; B130048E03; C2 GlcNAcT; C2GNT; IGnT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127835

InnateDB Gene

IDBG-150811 (Gcnt1)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O- glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. {ECO:0000269PubMed:7983056}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Also detected in the trans-Golgi network. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney, liver, stomach, spleen, lung and brain. {ECO:0000269PubMed:9341170}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0009101	glycoprotein biosynthetic process
GO:0048729	tissue morphogenesis
GO:0050901	leukocyte tethering or rolling
GO:0060352	cell adhesion molecule production
GO:0060993	kidney morphogenesis