InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF81

Summary

InnateDB Protein

IDBP-62081.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF81

Protein Name

zinc finger protein 81

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366153

InnateDB Gene

IDBG-62079 (ZNF81)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Mental retardation, X-linked 45 (MRX45) [MIM:300498]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269PubMed:15121780}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=A chromosomal aberration involving ZNF81 is found in a severe mental retardation patient. Translocation t(X;9)(p11.23;q34.3).

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding